A novel method for the mild and efficient synthesis of allyl sulfides has been developed
with allyl alcohols and thiols as substrates. The desired allyl sulfide was obtained
using a catalytic amount of Sn(OTf)2 in dichloromethane at room temperature after a reaction time of 12 hours. A diverse
range of allyl sulfides have been obtained with good to excellent yields, including
both linear and cyclic derivatives (27 products). Additionally, gram-scale reactions
can be easily carried out with only 1 mol% catalyst, giving over 90% yields, which
further proves the efficiency of our approach in synthesis. This methodology has both
deep research significance and application value, providing a new pathway to access
sulfide compounds. We strongly believe our method would be attractive to synthetic
chemists and would be widely used in synthetic chemistry.
Key words
allyl alcohols - allyl sulfides - allylic substitution - C–S bond formation - thiols
